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doi: 10.1016/S1470-2045(08)70200-6

Di Tucci, C., Galati, G., Mattei, G., Bonanni, V., Capri, O., D'Amelio, R., Muzii, L., & Benedetti Panici, P

These immune mechanisms are less susceptible to resistance mechanisms such as mutations, efflux pumps, and biofilm formation, making vaccines especially valuable against drug-resistant strains (Cassone, 2013

The brain is then able to launch a series of behavioral and physiologic reactions together named the sickness behavior, which include, fever, reduced appetite, weariness, social withdrawal, and disturbed sleep patterns