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Morbidity Chronic infection causes organ damage, including thickening and irregularities of the gallbladder wall, presence of sludge and enlargement of the gallbladder, dilatation and periductal fibrosis of bile duct (68, 72, 128130)

Interestingly, HNF-4 has also been involved in the epigenetic regulation of glycolytic enzymes by HBV to meet the increased energy demand of infected cells (96)