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administration of heroin can increase extracellular dopamine concentrations over a time scale of several minutes (e.g., [149, 150])

Instead, macrophages of the M2 phenotype do not have a clear counterpart in the transcriptional subsets, but its protein markers arginase and mannose receptor are found more in the shoulder regions covering the lipid core region and are less prone to develop into foam cells ( The metabolic pathways of glycolysis, the TCA and OXPHOS cycle, the PPP, lipid as well as amino acid metabolism play an important role in macrophage polarization and subsequently their inflammatory phenotype and contribution to atherosclerotic plaques (Koelwyn et al., 2018

Moreover, more recently a family of proteins called peroxiredoxins has been recognized as catalyzing the reduction of H 2 O 2 by GSH and/or other thiols, but with cysteine in its thiolate form, in their active sites rather than selenium-cysteine (Dickinson and Forman, 2002)