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These pathophysiological changes observed in humans have been further explored in animal models, where chronic intermittent hypoxia has been associated with oxidative stress, persistent sympathetic overactivation, myocardial fibrosis, and vascular and renal sclerosis [55]

Glutathione-s-transferases (GSTs) form a group of enzymes that are present in high concentrations in the cytosol and catalyze a wide variety of substitution reactions in which glutathione (GSH) replaces an easily displaced group on the xenobiotic, and thus prevents the subsequent toxic reactions 52

We found that regardless of simple nucleus pulposus removal or LIF, the symptoms of patients showed good recovery, which further shows that surgery for patients with LDH is positive

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