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doi: 10.1038/s41593-018-0296-9, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Parhizkar S., Holtzman D

It can also rise for several different reasons, and those reasons do not carry the same level of risk

Studies in animal models, such as hypertensive mice and rats and apolipoprotein E-deficient mice, have demonstrated that oxidative depletion of BH 4 leads to increased eNOS-derived superoxide, which impairs vasorelaxation (Hong et al., 2001