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Stams T, Spurlino JC, Smith DL, Wahl RC, Ho TF, Qoronfleh MW, et al

3.4 Immune modulatory mechanisms of probiotic in SLE Early on in the inflammatory process, changes in innate immune cells within the intestines have been observed, including mast cells, dendritic cells, neutrophils, and macrophages

Preclinical research implications First and foremost, we need more studies testing brain interventions and brain mechanisms because this type of detailed work is unethical or impractical in humans