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Regulatory and safety status: TA-1 is pending FDA review and not currently approved for use in humans

The review pointed to limited safety and effectiveness data, no approved product anywhere in the world, no major pharmacy-standard monograph, signal fade with chronic dosing, and concerning animal findings

It is a fragment derived from a naturally occurring protective protein identified in gastric juice and is widely studied in laboratory models of cellular signalling and tissue repair pathways

To explore the functions and signaling pathways linked to the ferroptosis-related risk signature, DEGs were subjected to GSEA