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(Han and Smith, in vitro studies performed by our research group have shown that co-administration of conventional chemotherapeutic agents with antioxidants such as melatonin enhances chemotherapeutic-induced cytotoxicity and apoptosis in different cancer cell lines (Uguz et al., 2012

Mobile phase A and B was 0.2% (v/v) AA in water (Optima grade, Fisher Scientific, USA) and 0.2% (v/v) AA in LC-MS grade acetonitrile (Honeywell, USA), respectively

Metformin, which is well-tolerated due to extensive clinical experience in diabetes management, has shown promising epidemiological associations with reduced cancer incidence and improved outcomes in some studies