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Many hepatokines have been linked to the induction of metabolic dysfunction ( This process begins with increased energy availability, which leads to lipid accumulation in the liver and local infiltration and activation of immune cells ( Here, we will focus on the hepatokines and factors released by the steatotic liver that have been found to regulate pancreatic islet cell function and mass as a consequence of organ crosstalk ( Table 1 )

J Postgrad Med

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