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APAP is bioactivated to N -acetyl p -benzoquinone imine (NAPQI), a reactive metabolite, which can subsequently covalently bind to glutathione and protein thiols

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When excessive ROS occurs, the dynamic balance of the two will be disordered and dysregulated, which will cause metabolic disorders and decreased immune function, form a chain reaction of oxygen free radicals, start lipid peroxidation reaction, and thus cause ferroptosis of cells [35, 36]

One peptide, two legal identities: form matters A topical cosmetic form and an injectable form of the same peptide can have completely different legal status