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Applichem GmbH, Germany) and 1% BSA in PBS, for 30 min at 4 C, and were immediately scraped into lysis buffer, to reveal the endocytosed pool of molecules

According to the FDA's press release it agreed to approve the drug for obesity based on three randomised, double-blind, placebo-controlled trials during which more than 2,600 patients received Wegovy for up to 68 weeks and more than 1,500 patients received placebo (US FDA 2021)

Screening of non-syndromic early-onset child and adolescent obese patients in terms of LEP, LEPR, MC4R and POMC gene variants by next-generation sequencing

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