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From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders

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After inducing expression of GFP-tagged wild-type or mutant FUS/TLS in HeLa cells, endogenous FUS/TLS was reduced by transfection of an siRNA targeting a sequence in the 3 untranslated region of the endogenous FUS/TLS gene, but missing from transgenes (Fig

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