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However, more prospective studies are required to define the best dose and duration for riboflavin supplementation in these patients

Finally, -butyrobetaine hydroxylase catalyzes the hydroxylation of - N -trimethylaminobutyrate to generate L-carnitine, requiring Fe 2+ and ascorbate

This work was supported by the Lions Eye Institute Flow Cytometry and Histology facilities and by the following Monash University platforms: Monash Animal Research Platform, Monash Macromolecular Crystallization Facility, FlowCore, Monash Micro Imaging, and Monash Histology