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Symptoms of a vitamin B12 deficiency include: Anemia Fatigue and weakness Dizziness Memory loss or concentration Rapid heartbeat Excessive bruising Soreness of the mouth or tongue Although there is no solid medical research to support these claims, many people believe that Vitamin B12 is helpful in improving concentration and boosting energy, as well as preventing or improving the following conditions: macular degeneration, a weakened immune system, infertility, sleep disorders, allergies, asthma, skin disorders and heart or kidney problems

Topical treatments for melasma: A systematic review of randomized controlled trials

Am J Med Genet 2001

Their mechanism of action involves the inhibition of COX enzymes, which are instrumental in the synthesis of prostaglandinschemical messengers implicated in the inflammatory response