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10.1146/annurev-biochem-011520-105053 16

These disturbances, often influenced by intricate genetic determinants, can trigger multiple forms of programmed death in dopaminergic neurons, among which ferroptosis plays a significant role (119, 124)

ATF4 integrates stress and metabolic signals through heterodimerization with members of the C/EBP family or with nuclear factor erythroid 2-related factor 2 (NRF2) to coordinate adaptive transcriptional programs (80-82)