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The charged nature of GSH (negative at physiological pH) suggests that GSH cannot passively diffuse into the mitochondria, because the mitochondrial matrix has a negative potential relative to the cytoplasm

Observed effects are dependent on concentration, cellular context, and experimental design, and are used to investigate molecular mechanisms rather than defined physiological outcomes

Conversely, KEAP1 downregulation (Supplementary Figure S6E) sensitised EGFRm/T790M PC9ER cells to erlotinib (Figure 3g), accompanied by the increased GSH levels (Figure 3h) and increased transcription of GSH-synthesising enzymes GCLC, GSR and GSS (Supplementary Figure S6F)

Mold Exposure and Mycotoxins: A Unique Challenge Mycotoxins are toxic substances released by molds like Aspergillus, Penicillium, and Stachybotrys found in water-damaged buildings