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Both impaired insulin secretion and insulin resistance may result from mitochondrial dysfunction, high production of reactive oxygen species, and low levels of adenosine triphosphate [31,32]

Notably, we observed that different patients had fine-detailed differences in bile canaliculus morphology, with some patients having thin and homogenous bile canaliculi, some having wider and inhomogeneous bile canaliculi and others having bile canaliculi full of branchlets (Extended Data Fig

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