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These findings laid the groundwork for the first human trial of AAV-mediated RNAi therapy, which reported a remarkable 45% reduction in HTT levels without inducing neuropathological abnormalities or adverse effects (McBride et al

3.3 Inflammation-induced immune cell activation Aberrant immune activation, occurring both within the CNS and throughout the bodys peripheral systems, contributes directly to the intertwined pathologies of EDC

In a coupled assay with the Trx system (Trx/Trx reductase), rates of peroxide reduction were determined by indirectly monitoring NADPH oxidation as a decrease in absorbance at 340 nm

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