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Department of Energy, Basic Energy Science and the Canadian Light Source

For instance, smaller particles with a more neutral surface charge are less likely to cause irritation and inflammation [336,337,338]

Spermatogenesis was affected in bulls following oral dosing with 2 mg/kg per day for less than 21 days and in rabbits following subcutaneous injection of 15 mg/kg for 5 days

Advanced DDS with precise targeting can lead to the accumulation of nanoparticles at the target site, where undesired interactions can occur, resulting in neurotoxicity mediated by oxidative stress, disruption of membrane integrity, and DNA damage (Zhang et al., 2021