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The risk of developing acute diverticulitis among those with diverticulosis is around 10-25% over a lifetime [10], and individuals experiencing complicated diverticulitis can face short-term mortality rates exceeding 8%, with long-term rates climbing to nearly 15% if perforation occurs [11]

Beyond surface modification, exosome-encapsulated therapeutic agents also leverage inherent biocompatibility of exosomes to cross biological barriers

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This makes it particularly valuable during winter months when sun exposure is limited and vitamin D synthesis becomes impossible at northern latitudes