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doi: 10.1002/lol2.10263

In OA models, ACSL4 inhibition dramatically decreases ferroptosis-associated lipid peroxidation ( in vitro models, inhibiting cartilage chondroptosis and improving OA ( Excessive lipid metabolic reprogramming in OA significantly raises ferroptosis risk, so targeting lipid synthesis, transport, and degradation represents a promising upstream approach to reducing ferroptotic damage

Research has shown niacinamide and tranexamic acid work particularly well together, and as mentioned above, it can be used with other discolouration-reducing ingredients such as all forms of vitamin C, liquorice, retinol and bakuchiol

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