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Currently, there are over 70 million people in the worlds oldest group, over 80 years

Giancaterini A, De Gaetano A, Mingrone G, et al

Long-term LC supplementation has been shown to elevate fasting plasma TMAO levels, raising concerns about its implications for cardiovascular health, despite its potential benefits in improving muscle mass and physical performance

In HPBECs, aminophylline promoted mitochondrial biogenesis by activating the CREB-PGC-1 signalling pathway, and its impact was reflected in the increase of the mtDNA/nDNA ratio, elevation of mitochondrial protein cytochrome B, and enhancement of mitochondrial respiratory rate and ATP production (Wei et al., 2019)