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The highest resolution achieved in cryo-EM for protein structure determination is currently 1.25 (as reported for apoferritin, which is composed of 24 subunits arranged in a symmetrical structure, with a total molecular mass of 440480 kDa) (Yip et al., 2020)

A Category 1 designation can be resolved in either direction: the FDA may determine the compound is appropriate for compounding (moving it to an approved list) or inappropriate (moving it to Category 2)

therefore, intermittent phototherapy was administered as treatment in this regard until the skin staining subsided