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Rose and Witebsky were able to demonstrate how immunization of certain rodents with extracts of other rodents' thyroid resembled the disease that Hakaru and other researchers were trying to describe

this growth factor can be secreted by many cell types including macrophages, tumor cells, and fibroblasts (171)

While lipoid acid blocks oxidative stress, as it does not chelate to heavy metals, it is often used in combination with chelating agents, DMSA (2,3-dimercaptosuccinic acid) in particular

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