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The study demonstrated that glutamine improved IL-13-induced barrier dysfunction by up-regulating the expression of the tight junction protein claudin-1, through preventing the PI3K-Akt signaling pathway (Li et al., 2021), and consequently damaged the intestinal barrier function and increased intestinal permeability

This result may be due to the low percentage of functional thyroid tissue in children with cretinism in which T4 is converted to active T3 at the periphery in the presence of Se supplementation only