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(2013) conducted a formal pharmacokinetic study in nine healthy male volunteers, establishing a biphasic profile: a rapid distribution phase of approximately 7.6 minutes followed by an elimination phase of approximately 2.5 hours

no large-scale controlled human clinical trials establishing safety or efficacy currently exist

Which of the two forms to use is one of the most-debated questions around this pairing, and the common recommendation No-DAC happens to line up with the pharmacology