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Some studies have shown that cisplatin forms a complex with reduced glutathione in the liver and then enters the kidney

The presence of vitamin B12 deficiency can manifest through a number of unpleasant symptoms, such as: fatigue and lack of energy irregular heartbeat or palpitations loss of appetite and weight loss depression and irritability headaches and feeling of pins and needles mental declines in memory, judgement, and comprehension disturbed or blurry vision changes in motor skills, like the way you walk changes in skin colour, such as paleness or a yellow tinge tongue redness and soreness Some of these symptoms can occur in people who have low or deficient levels of vitamin B12 but have not yet developed severe cases of anaemia

A nationwide survey of DPN in Germany showed that 61.5% and 81.1% of patients with painful and painless DPN were undiagnosed previously [3]

PMID: 29367537