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While glutathione is a natural antioxidant, supplement usage is a different category and requires proven safetywhich is currently lacking

Chena J, Gaoa Y, Xua Z, Wu G, Chena Y, Zhub C (2006) A novel fluorescent array for mercury (II) ion in aqueous solution with functionalized cadmium selenide nanoclusters

Reports also show that intravenous administration of PACAP-38 can elicit a migraine-like attack in patients (Schytz et al., 2009) and cause sustained meningeal vasodilation and migraine-like photophobia in mice (Markovics et al., 2012)