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doi: 10.1016/j.freeradbiomed.2023.03.027 18 ZhaoTYangQXiYXieZShenJLiZet al

Aoi W, Ogaya Y, Takami M, Konishi T, Sauchi Y, Park EY, et al

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Unlike existing reviews that primarily discuss PROTAC biology, degrader chemistry, or delivery systems in a more general manner, this review focuses specifically on the chemistry-guided design logic of smart delivery systems for PROTACs and on how the unique structural and physicochemical features of PROTACs impose distinct delivery requirements