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First, we further validated the role of PrP in dose-response experiments

In cystic fibrosis patients, who secrete lower GSH than normal individuals into the lining fluid covering their alveoli, and in smokers, who have exposed their lungs to many oxidants including nitrogen dioxide and H 2 O 2 , there is both chronic inflammation and lower than normal GSH (Roum et al., 1993)

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Indeed, oxidative stress associated with excessive ROS production and depletion of the antioxidant system is commonly observed in nanomaterial-induced eryptosis [452,453,454,455,456,457]