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Both supplements contribute to overall health but target different aspects of cellular function

These options have different evidence bases, mechanisms, and adverse-effect profiles from KLOW

Finally, it is crucial to explore the key enzymes involved in CAT production by gut microbiota metabolism and their regulatory factors, evaluate the therapeutic potential of engineered probiotics (e.g., CAT-synthesizing strains) or exogenous CAT delivery systems (e.g., cartilage-targeted nanocarriers) for OA, and provide multi-level evidence for CAT-targeted OA therapy based on the gut-joint axis

[4] Cold is most effective at relieving pain and swelling during the first 3 days after the injury, but after that, using heat can help relax the area and may increase circulation, which can promote healing