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Biotin deficiency is rare but can occur in specific groups: High-Risk Groups: People with metabolic disorders or malnutrition Alcoholics and athletes Epilepsy patients , elderly , and those with gastrointestinal surgery Pregnant women (studies show 50% develop deficiency due to increased vitamin demand) Diabetes patients Dietary Causes: Long-term consumption of raw egg whites contains avidin , a protein that binds biotin and prevents absorption

Additionally, Tianlongkechuanling (TL) mitigates fibrosis by reducing the expression of multiple arginine cycle enzymes, including arginase-1, CPS1, OTC, ASS1, OAT, ASL, and iNOS, helping to restore the balance between arginase and NO synthase pathways [140]