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Even a single amino acid substitution can dramatically alter the peptide's properties and render it ineffective

doi: 10.21037/sci

In this study, myosteatosis was associated with poorer OS and PFS in patients treated with PD-1 inhibitor plus tyrosine kinase inhibitors, but showed a protective effect on PFS in those receiving PD-1 plus CTLA-4 blockade, potentially due to differences in immune cell composition and checkpoint expression within the TME [141]