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(2014) argue that autophagy inhibition can be employed independently of TP53 status, reducing the oxygen consumption rate and clonogenicity (Yang et al., 2011, 2014

In the Phase I/II trial, 27% of patients with indolent lymphoma achieved objective clinical responses at distant, noninjected tumor sites following intratumoral injection of the TLR9 agonist PF-3512676 combined with low-dose radiotherapy, including one complete and three partial responses

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