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Secondly, mutations in TyrRS result in dominant-intermediate CMT disease (DI-CMT) characterized by slow progressive neuropathy, intermediate nerve conduction velocities, axonal degeneration, and demyelination of peripheral motor and sensory neurons

Furthermore, the endogenous H 2 S generation pathway using D-Cys as a substrate primarily functions in the cerebellum and kidneys, which are 7-and 80-fold higher than the source of L-Cys as a substrate generation pathway, respectively

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