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Elena: And in the transition, so the big step can be, and I dont want to talk about psychiatric diseases because I know you have to be really careful

[14] Noradrenergic and serotonergic nuclei in the ARAS are involved in the regulation of the REM sleep cycle and function as "REM-off" cells, with amphetamine's effect on norepinephrine and serotonin contributing to the suppression of REM sleep and a possible reduction of cataplexy at high doses

According to the FDA prescribing information, gastrointestinal adverse reactions are among the most commonly reported side effects of tirzepatide, occurring in a dose-dependent manner