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HNE has been detected in vivo in several pathological conditions characterized by increased lipid peroxidation, including inflammation, atherosclerosis, chronic degenerative diseases of the nervous system, and chronic liver diseases (Moreau et al., 2005)

Barron noted in 1920 that ligation of the pancreatic duct, with destruction of the exocrine pancreas, only resulted in DM if the islets, so named by Langerhans in 1869 , were also destroyed

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Overview of amino acid metabolism Amino acids are organic compounds containing amino and carboxyl groups, which can be divided into -, -, -, - amino acids according to the position of the functional groups of the core structure, the most important of which are the 22 alpha-amino acids that make up proteins and 20 of these amino acids are involved in protein synthesis