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doi: 10.1186/s13167-016-0059-1

This is a formidable, often moving-target objective

In biopsies taken from clinically healthy perilesional areas of the scalp, microscopic abnormalities include a 66% increased telogen rate, increased vellus hair count, and miniaturization [54]

He hypothesized that lactic acidosis, increased concentration of Krebs cycle metabolites in urine, reduced levels of carnitine in plasma, decreased utilization of glucose in the brain, and lowered ATP levels in these patients are associated with mitochondrial dysfunction [66]