10.1016/j.biomaterials.2019.119457 231 WuQ.YaoJ.XiaoM.ZhangX.ZhangM.XiX

Daniel Strbian: Scientific advisory board Boehringer-Ingelheim and Astra Zeneca E-Posters - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P2543 - ESOC25-1742 OLD ISCHEMIC LESIONS ON MRI IN THE EMERGENCY DEPARTMENT ASSOCIATED COMORBIDITIES OF ACUTE STROKE AND TIA VERSUS NON-STROKE CONDITIONS Malini Sagar 1,2 , Christian Krag 2,3,4 , Karen Lind Gandrup 3 , Mikael Boesen 2,4,5 , Christina Kruuse 1,2,6 1 Department of Neurology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark, 2 Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 3 Department of Radiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark, 4 Radiological AI Test Center (RAIT.dk), Copenhagen University Hospital - Herlev and Gentofte & Bispebjerg and Frederiksberg, Copenhagen, Denmark, 5 Department of Radiology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark, 6 Department of Brain and Spinal Cord Injury, Copenhagen University Hospital - Rigshospitalet Glostrup, Glostrup, Denmark Background and Aims: Old ischemic lesions on magnetic resonance imaging (MRI), among patients without ischemic stroke or transitory ischemic attack (TIA), cause occasional therapeutic dilemmas

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Understanding this multi-level regulation across scales, from molecular and cellular to circuit and system levels, is fundamental for elucidating exercise-mediated neuroprotective mechanisms and cognitive intervention strategies