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[18] CNS infection with HHV-6 is a major cause of seizures in children, as well as more severe pediatric neurological disorders, including disseminated demyelination and infarction of the basal ganglia

Since K1648R mutation of Mg 2+ -binding site on the kinase domain increased the IC 50 value to 2.5 M in the absence of [Mg 2+ ] i , it is suggested that intracellular Mg 2+ facilitates the binding of waixenicin A to TRPM7 (Zierler et al., 2011)

It offers advantages such as quick drug absorption, rapid onset of action, evasion of first-pass metabolism, and minimal systemic dilution