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Sappanone A similarly combats inflammation and ECM degradation in OA by attenuating chondrocyte ferroptosis through the SIRT1/Nrf2 pathway (165)

Growth Factors 9 , 5771 (1993)

In the cardiovascular system, succinate released by macrophages stimulated the production of inflammatory cytokine IL-1 by activating HIF-1, thus inducing endothelial inflammation and then promoting atherosclerosis

The only serious concern was that glutathione has a relatively short half-life in the bloodstream, which could potentially limit the duration of its efficacy