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Studies using cDC models have shown that ROS produced by DCs during antigen cross-presentation help maintain an alkaline environment within the phagosome, which is crucial for preserving the structure of internalized antigens and successfully presenting them via Major Histocompatibility Complex class I (MHC-I) complexes to CD8 + T cells [157]

SST is an endocrine inhibitory hormone, with its brain derivative, SST-14, expressed throughout the cortex 56

Some potential mechanisms for involvement of the microbiota include inflammation induced by low-grade endotoxemia, increased energy harvest from food, altered fatty acid metabolism, and variations in gut-derived peptide secretion