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Thus, by activating the coagulationinflammation axis, worsening the local microenvironment, promoting urate crystal aggregation, and accelerating tissue fibrosis, hypercoagulability contributes significantly to tophus development and persistence

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(1997, Journal of Endocrinology) reported that IGF-1 LR3 supported protein turnover in tumor-bearing catabolic rats but also increased tumor growth in that model