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Red blood cell breakdown (also known as hemolysis) in G6PD deficiency can manifest in many ways, including the following: Prolonged neonatal jaundice, possibly leading to kernicterus (arguably the most serious complication of G6PD deficiency) Hemolytic crises in response to: Illness (especially infections) Certain drugs (see below) Certain foods, most notably broad beans, from which the word favism derives Certain chemicals Diabetic ketoacidosis Hemoglobinuria (red or brown urine) Very severe crisis can cause acute kidney injury Favism is a hemolytic response to the consumption of fava beans, also known as broad beans

Such dysregulation has been linked to myriad pathologies, underscoring the clinical significance of maintaining ER redox homeostasis