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2020 Feb;16(3):145-154

doi: 10.3389/fneur.2021.615790 146 RustRChienCScheelMBrandtAUDorrJWuerfelJet al

When a cell faces irretrievable distress that is too strong to be adjusted for and to maintain homeostasis, it frequently activates specific signaling cascades leading to a particular cell death type [3]