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Preliminary collaboration throughout the translational pipeline is expected to produce more resilient preclinical modelling and clinical trial design

10.1093/brain/awh129 174 HawkinsK

Parallel to these endocrine perturbations, IR drives lipotoxicity and systemic inflammation, characterized by increased TNF-, IL-6, and C-reactive protein, which further suppresses insulin sensitivity and antioxidant enzyme expression (78)