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Direct increases in collagen mRNA production occur across the effective concentration range of 0.01 to 100 nanomolar

PGC1 activation is controlled via deacetylation of lysine residues by the deacetylase SIRT1 (15)

Across this body of work, the consistent findings are: reduced shedding within four to six weeks of consistent daily use, measurable increases in hair density at the temporal and crown regions over three to six months, and self-reported improvement in hair quality and scalp comfort that tracks with the in-vitro evidence on inflammation and oxidative stress