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62 DeLeoF

Primary hypothyroidism is considered to be the end stage of Hashimoto's thyroiditis

Indeed, the EC-derived organoids were found to replicate patient- and tumor-specific responses to drugs, an observation which was further expanded to discover patient-specific drug efficacy (personalized medicine) at higher throughput [70, 71]

Notably, ACAP2 bound GTP-Rab35 via its ankyrin repeat region, influencing Rab35-dependent neurite outgrowth by modulating Arf6 activity despite lacking Rab35-GAP function