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When self-assembling sequences are intended to be conjugated to bioactive sequences (i.e., peptides/proteins capable of modifying cellular behavior like adhesion, proliferation or differentiation), two strategies may be employed: i) synthesis of the entire biomolecule (self-assembling sequence + bioactive sequence) in a single process or ii) conjugation of the two sequences by chemoselective ligation recurring to bio-orthogonal functional groups that can react specifically and under mild conditions to form the final conjugate

Sanguigno L, Guida N, Anzilotti S, Cuomo O, Mascolo L, Serani A, et al

(Roberti et al., 2023) highlighted the preventive effects of NNMT blockade during the initial phases of adipogenesis, which inhibited preadipocyte differentiation into adipocytes in response to glucocorticoids

- La fertilit : Joue un rle important dans la sant reproductive, notamment chez les hommes, en maintenant la qualit du sperme et chez la femme, aide protger les ovaires et joue un rle important pour la maturation des ovocytes