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Non-healing wounds may sometimes indicate: Diabetes or insulin resistance Poor circulation Infection Nutritional deficiencies Autoimmune conditions Vascular disease Pressure injuries Other serious medical concerns These conditions require comprehensive medical evaluation

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A recent study on the effects of the SSRI paroxetine on salivary cortisol in major depressive disorder reported a "robust CAR increase especially when patients became remitters versus no change in non-remitters during paroxetine treatment" so CAR may additionally be used to assess clinical response to antidepressant therapy

The peptide initiates its action in the hypothalamus, leading to downstream effects on sexual desire and arousal (King et al., 2007)